Statin therapy in athletes and patients performing regular intense exercise - Position paper from the International Lipid Expert Panel (ILEP).
Identifieur interne : 000653 ( Main/Exploration ); précédent : 000652; suivant : 000654Statin therapy in athletes and patients performing regular intense exercise - Position paper from the International Lipid Expert Panel (ILEP).
Auteurs : Niki Katsiki [Grèce] ; Dimitri P. Mikhailidis [Royaume-Uni] ; Gani Bajraktari [Suède] ; Andre R. Miserez [Suisse] ; Arrigo F G. Cicero [Italie] ; Eric Bruckert [France] ; Maria-Corina Serban [Roumanie] ; Erkin Mirrakhimov [Kirghizistan] ; Fahad Alnouri [Arabie saoudite] ; Željko Reiner [Croatie] ; György Paragh [Hongrie] ; Amirhossein Sahebkar [Iran] ; Maciej Banach [Pologne]Source :
- Pharmacological research [ 1096-1186 ] ; 2020.
Descripteurs français
- KwdFr :
- Athlètes (MeSH), Consensus (MeSH), Dyslipidémies (traitement médicamenteux), Exercice physique (MeSH), Humains (MeSH), Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (effets indésirables), Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique), Maladies musculaires (induit chimiquement).
- MESH :
- effets indésirables : Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase.
- induit chimiquement : Maladies musculaires.
- traitement médicamenteux : Dyslipidémies.
- usage thérapeutique : Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase.
- Athlètes, Consensus, Exercice physique, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- chemically induced : Muscular Diseases.
- drug therapy : Dyslipidemias.
- chemical , therapeutic use : Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- Athletes, Consensus, Exercise, Humans.
Abstract
Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30 min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevation in statin-treated sport athletes. However it is worth emphasizing that abovementioned guidelines, previous and recent ESC/EAS consensus papers on adverse effects of statin therapy as well as other previous attempts on this issue, including the ones from the International Lipid Expert Panel (ILEP), give only general recommendations on how to manage patients requiring statin therapy on regular exercises. Therefore, these guidelines in the form of the Position Paper are the first such an attempt to summary existing, often scarce knowledge, and to present this important issue in the form of step-by-step practical recommendations. It is critically important as we might observe more and more individuals on regular exercises/athletes requiring statin therapy due to their cardiovascular risk.
DOI: 10.1016/j.phrs.2020.104719
PubMed: 32087236
Affiliations:
- Arabie saoudite, Croatie, France, Grèce, Hongrie, Iran, Italie, Kirghizistan, Pologne, Roumanie, Royaume-Uni, Suisse, Suède
- Angleterre, Grand Londres, Île-de-France
- Londres, Paris
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation></author><author><name sortKey="Banach, Maciej" sort="Banach, Maciej" uniqKey="Banach M" first="Maciej" last="Banach">Maciej Banach</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland. Electronic address: maciejbanach77@gmail.com.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora</wicri:regionArea><wicri:noRegion>Zielona Gora</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32087236</idno><idno type="pmid">32087236</idno><idno type="doi">10.1016/j.phrs.2020.104719</idno><idno type="wicri:Area/PubMed/Corpus">000167</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000167</idno><idno type="wicri:Area/PubMed/Curation">000166</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000166</idno><idno type="wicri:Area/PubMed/Checkpoint">000089</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000089</idno><idno type="wicri:Area/Main/Merge">000653</idno><idno type="wicri:Area/Main/Curation">000653</idno><idno type="wicri:Area/Main/Exploration">000653</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Statin therapy in athletes and patients performing regular intense exercise - Position paper from the International Lipid Expert Panel (ILEP).</title><author><name sortKey="Katsiki, Niki" sort="Katsiki, Niki" uniqKey="Katsiki N" first="Niki" last="Katsiki">Niki Katsiki</name><affiliation wicri:level="1"><nlm:affiliation>First Department of Internal Medicine, Division of Endocrinology and Metabolism, Diabetes Center, Medical School, AHEPA University Hospital, Thessaloniki, Greece. Electronic address: nikikatsiki@hotmail.com.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>First Department of Internal Medicine, Division of Endocrinology and Metabolism, Diabetes Center, Medical School, AHEPA University Hospital, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Mikhailidis, Dimitri P" sort="Mikhailidis, Dimitri P" uniqKey="Mikhailidis D" first="Dimitri P" last="Mikhailidis">Dimitri P. Mikhailidis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bajraktari, Gani" sort="Bajraktari, Gani" uniqKey="Bajraktari G" first="Gani" last="Bajraktari">Gani Bajraktari</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Cardiology, University Clinical Centre of Kosovo, Prishtina, Kosovo, Serbia; Medical Faculty, University of Prishtina, Prishtina, Kosovo, Serbia; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Clinic of Cardiology, University Clinical Centre of Kosovo, Prishtina, Kosovo, Serbia; Medical Faculty, University of Prishtina, Prishtina, Kosovo, Serbia; Department of Public Health and Clinical Medicine, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Miserez, Andre R" sort="Miserez, Andre R" uniqKey="Miserez A" first="Andre R" last="Miserez">Andre R. Miserez</name><affiliation wicri:level="1"><nlm:affiliation>Diagene Research Institute, Reinach, Switzerland; University of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Diagene Research Institute, Reinach, Switzerland; University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Cicero, Arrigo F G" sort="Cicero, Arrigo F G" uniqKey="Cicero A" first="Arrigo F G" last="Cicero">Arrigo F G. Cicero</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine and Surgery Sciences, University of Bologna, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medicine and Surgery Sciences, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Bruckert, Eric" sort="Bruckert, Eric" uniqKey="Bruckert E" first="Eric" last="Bruckert">Eric Bruckert</name><affiliation wicri:level="3"><nlm:affiliation>Pitié-Salpêtrière Hospital and Sorbonne University, Cardio Metabolic Institute, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pitié-Salpêtrière Hospital and Sorbonne University, Cardio Metabolic Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Serban, Maria Corina" sort="Serban, Maria Corina" uniqKey="Serban M" first="Maria-Corina" last="Serban">Maria-Corina Serban</name><affiliation wicri:level="1"><nlm:affiliation>Department of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara</wicri:regionArea><wicri:noRegion>Timisoara</wicri:noRegion></affiliation></author><author><name sortKey="Mirrakhimov, Erkin" sort="Mirrakhimov, Erkin" uniqKey="Mirrakhimov E" first="Erkin" last="Mirrakhimov">Erkin Mirrakhimov</name><affiliation wicri:level="1"><nlm:affiliation>Kyrgyz State Medical Academy, Named after Akhunbaev I.K., Bishkek, Kyrgyzstan.</nlm:affiliation><country xml:lang="fr">Kirghizistan</country><wicri:regionArea>Kyrgyz State Medical Academy, Named after Akhunbaev I.K., Bishkek</wicri:regionArea><wicri:noRegion>Bishkek</wicri:noRegion></affiliation></author><author><name sortKey="Alnouri, Fahad" sort="Alnouri, Fahad" uniqKey="Alnouri F" first="Fahad" last="Alnouri">Fahad Alnouri</name><affiliation wicri:level="1"><nlm:affiliation>Cardiovascular Prevention Unit, Adult Cardiology Department, Prince Sultan Cardiac Centre Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Cardiovascular Prevention Unit, Adult Cardiology Department, Prince Sultan Cardiac Centre Riyadh</wicri:regionArea><wicri:noRegion>Prince Sultan Cardiac Centre Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Reiner, Zeljko" sort="Reiner, Zeljko" uniqKey="Reiner Z" first="Željko" last="Reiner">Željko Reiner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Diseases University Hospital Center Zagreb School of Medicine, Zagreb University, Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>Department of Internal Diseases University Hospital Center Zagreb School of Medicine, Zagreb University, Zagreb</wicri:regionArea><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Paragh, Gyorgy" sort="Paragh, Gyorgy" uniqKey="Paragh G" first="György" last="Paragh">György Paragh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen</wicri:regionArea><wicri:noRegion>Debrecen</wicri:noRegion></affiliation></author><author><name sortKey="Sahebkar, Amirhossein" sort="Sahebkar, Amirhossein" uniqKey="Sahebkar A" first="Amirhossein" last="Sahebkar">Amirhossein Sahebkar</name><affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation></author><author><name sortKey="Banach, Maciej" sort="Banach, Maciej" uniqKey="Banach M" first="Maciej" last="Banach">Maciej Banach</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland. Electronic address: maciejbanach77@gmail.com.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora</wicri:regionArea><wicri:noRegion>Zielona Gora</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pharmacological research</title><idno type="eISSN">1096-1186</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Athletes (MeSH)</term><term>Consensus (MeSH)</term><term>Dyslipidemias (drug therapy)</term><term>Exercise (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects)</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)</term><term>Muscular Diseases (chemically induced)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Athlètes (MeSH)</term><term>Consensus (MeSH)</term><term>Dyslipidémies (traitement médicamenteux)</term><term>Exercice physique (MeSH)</term><term>Humains (MeSH)</term><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (effets indésirables)</term><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique)</term><term>Maladies musculaires (induit chimiquement)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Muscular Diseases</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dyslipidemias</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Maladies musculaires</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Dyslipidémies</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Athletes</term><term>Consensus</term><term>Exercise</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Athlètes</term><term>Consensus</term><term>Exercice physique</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30 min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevation in statin-treated sport athletes. However it is worth emphasizing that abovementioned guidelines, previous and recent ESC/EAS consensus papers on adverse effects of statin therapy as well as other previous attempts on this issue, including the ones from the International Lipid Expert Panel (ILEP), give only general recommendations on how to manage patients requiring statin therapy on regular exercises. Therefore, these guidelines in the form of the Position Paper are the first such an attempt to summary existing, often scarce knowledge, and to present this important issue in the form of step-by-step practical recommendations. It is critically important as we might observe more and more individuals on regular exercises/athletes requiring statin therapy due to their cardiovascular risk.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Croatie</li><li>France</li><li>Grèce</li><li>Hongrie</li><li>Iran</li><li>Italie</li><li>Kirghizistan</li><li>Pologne</li><li>Roumanie</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Paris</li></settlement></list><tree><country name="Grèce"><noRegion><name sortKey="Katsiki, Niki" sort="Katsiki, Niki" uniqKey="Katsiki N" first="Niki" last="Katsiki">Niki Katsiki</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mikhailidis, Dimitri P" sort="Mikhailidis, Dimitri P" uniqKey="Mikhailidis D" first="Dimitri P" last="Mikhailidis">Dimitri P. Mikhailidis</name></region></country><country name="Suède"><noRegion><name sortKey="Bajraktari, Gani" sort="Bajraktari, Gani" uniqKey="Bajraktari G" first="Gani" last="Bajraktari">Gani Bajraktari</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Miserez, Andre R" sort="Miserez, Andre R" uniqKey="Miserez A" first="Andre R" last="Miserez">Andre R. Miserez</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Cicero, Arrigo F G" sort="Cicero, Arrigo F G" uniqKey="Cicero A" first="Arrigo F G" last="Cicero">Arrigo F G. Cicero</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Bruckert, Eric" sort="Bruckert, Eric" uniqKey="Bruckert E" first="Eric" last="Bruckert">Eric Bruckert</name></region></country><country name="Roumanie"><noRegion><name sortKey="Serban, Maria Corina" sort="Serban, Maria Corina" uniqKey="Serban M" first="Maria-Corina" last="Serban">Maria-Corina Serban</name></noRegion></country><country name="Kirghizistan"><noRegion><name sortKey="Mirrakhimov, Erkin" sort="Mirrakhimov, Erkin" uniqKey="Mirrakhimov E" first="Erkin" last="Mirrakhimov">Erkin Mirrakhimov</name></noRegion></country><country name="Arabie saoudite"><noRegion><name sortKey="Alnouri, Fahad" sort="Alnouri, Fahad" uniqKey="Alnouri F" first="Fahad" last="Alnouri">Fahad Alnouri</name></noRegion></country><country name="Croatie"><noRegion><name sortKey="Reiner, Zeljko" sort="Reiner, Zeljko" uniqKey="Reiner Z" first="Željko" last="Reiner">Željko Reiner</name></noRegion></country><country name="Hongrie"><noRegion><name sortKey="Paragh, Gyorgy" sort="Paragh, Gyorgy" uniqKey="Paragh G" first="György" last="Paragh">György Paragh</name></noRegion></country><country name="Iran"><noRegion><name sortKey="Sahebkar, Amirhossein" sort="Sahebkar, Amirhossein" uniqKey="Sahebkar A" first="Amirhossein" last="Sahebkar">Amirhossein Sahebkar</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Banach, Maciej" sort="Banach, Maciej" uniqKey="Banach M" first="Maciej" last="Banach">Maciej Banach</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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